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This study aimed to estimate the state of bone mass, microarchitecture, and factors linked with vertebral fracture among postmenopausal females with type 2 diabetes mellitus (T2DM).
The postmenopausal
women with type 2 diabetes mellitus exhibit significant associations with the
declined trabecular bone score and low bone mass and the risk inclined in women
who are old and with poor glycemic control. The study results affirm that bone
strength together with clinical risk factors found to have the strongest
association with fracture and may be useful to identify women with T2DM at risk
of fracture.
This study aimed to
estimate the state of bone mass, microarchitecture, and factors linked with
vertebral fracture among postmenopausal females with type 2 diabetes mellitus
(T2DM).
A total of 285
females aged 60.7 ± 6.9 years went through bone trabecular bone score (TBS) and
mineral density (BMD) evaluation using T8-S1 lateral spine radiographs;
laboratory evaluation; dual-energy x-ray absorptiometry; and interviews
concerning clinical risk factors on the basis of the fracture risk assessment
tool (FRAX).
Women with T2DM
exhibited 72.6%, and 63.2% declined bone microarchitecture and low bone mass,
respectively. TBS showed an association with femoral neck, total hip BMD, and
lumbar spine. Further, the normal BMD, osteoporosis, and osteopenia groups
exhibited considerable differences in the TBS scores. Bone-specific alkaline
phosphatase, age, and vertebral fracture were remarkably different in groups
with several T scores or those ranked by TBS classes. Bone-specific alkaline
phosphatase was positively associated with glycated haemoglobin but inversely
associated with TBS and BMD. BMD exhibited a weaker relationship with vertebral
fracture than TBS, FRAX, TBS-adjusted FRAX, and TBS and BMD.
About two-thirds of
T2DM females showed declined TBS and low bone mass and a correlation with
vertebral fracture. Along with ageing, poor glycemic control may perform a
crucial function in bone remodeling, which may be due to the alterations in
bone strength among T2DM females. Bone strength concurrently with clinical risk
factors showed a marked connection with fracture and may be beneficial to
recognise females with T2DM at risk of fracture.
Menopause
Status of bone strength and factors associated with vertebral fracture in postmenopausal women with type 2 diabetes.
Chen FP et al.
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