Non-steroidal anti-inflammatory drugs (NSAIDs) are common drugs that exhibits analgesic and anti-inflammatory effects. They are widely used in treatment of pain and fever in adults as well as pediatric population. It is a Cochrane review study that analysed different randomized double blind controlled trials to assess the effects of NSAIDs in children suffering from chronic pain and evaluated that there are limited RCTs in history related to this context.

To determine the non‐steroidal anti‐inflammatory drugs (NSAIDs)  effectiveness and adverse effects that treat cancer‐related pain among children and adolescents in any setting.

MEDLINE, CENTRAL, and Embase were searched from inception to 21 February 2017 for collecting associated data. The reference lists of retrieved studies and reviews along with online clinical trial registries were also explored. The assessment of studies for eligibility was done by two authors independently. The dichotomous data was used to estimate the risk ratio and number needed to operate for one further event, using standard methods. The evaluation of GRADE was done and planned to design a 'Summary of findings' table.

No studies were suitable for inclusion. Investigators demoted the quality of evidence by three levels due to the shortage of data listed for any outcome.

No evidence was reported that NSAIDs could decrease cancer‐related pain among children and adolescents.