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The major part of the hip osteoarthritis (OA) physiopathology is neuroimmune axis, however, its particular pathways are still unclear.
Hip osteoarthritis (OA) is a severe health
condition and a major cause of pain and disability among adults. Neuroimmune
axis have been established an important player in the pathogenesis of hip OA.
Despite the availability of many studies, none of them demonstrate the general
profile of neuroimmune expression OA. Therefore, a systemic review conducted by
Manuel Ribeiro da Silva et al found the upregulation of neuroimmune markers,
with the deregulated balance between pro and anti-inflammatory cytokines in
patients with hip OA.
The major part of the hip osteoarthritis (OA)
physiopathology is neuroimmune axis, however, its particular pathways are still
unclear. This systematic review intends to evaluate the immune and nervous
system profile of the individuals with hip osteoarthritis (OA) as compared to
the healthy controls.
PRISMA guidelines were followed and conducted the
systematic review. A two-step election process was performed, and 17 references
were involved. Original articles on adult individuals with hip OA along with
the evaluation of neuroimmune expression was taken for the inclusion criteria.
Some of the articles were excluded who were without a control group or with
other interventions before analysis.
A total of 39 relevant neuroimmune markers were
recognised with evaluations in cartilage, bone, whole blood, immune cells,
serum, synovial fluid, and synovial membrane. During the comparison between
controls and hip OA, IFN-γ, TNF-α, IL-1, IL-6, IL-8, IL-1α, and GM-CSF
exhibited variable expression among tissues.
TGF-ß and VEGFs isoforms displayed comparable tendencies amid tissues
and studies. On nervous expression, Tuj-1, SP, and CGRP were raised in the
synovial membrane. All-inclusive, individuals with hip OA showed a greater
number of overexpressed markers.
For the first time, a systematic review on neuroimmune
expression within persons with hip OA discovered an upregulation of neuroimmune
markers, with a deregulated balance within pro and anti-inflammatory cytokines.
Although, no clear systematic pattern was observed, and less data is available
on nervous expression. This enlightens the importance of prospective investigation
with clear methodologies to guide the management of such cases.
BMC Musculoskeletal Disorders
Neuroimmune expression in hip osteoarthritis: a systematic review
Manuel Ribeiro da Silva et al.
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