Metabolic syndrome (MetS) has been shown to induce oxidative stress (OxS). This study clarifies the association of MetS with osteoarthritis and found a shift in the serum of OA patients, as indicator of of high-grade OxS and dysglycemia and the OA severity and MetS were independently associated with oxLDL. 

Earlier investigations propose that metabolic disturbances might be correlated with the osteoarthritis (OA) development. Relationships have been observed among OA and the individual components of metabolic syndrome (MetS). MetS have been linked with enhanced oxidative stress (OxS). This study clarifies the MetS components role in OA and to assess the levels of OxS in OA subjects and in age-matched controls.

A total of 55 individuals with end-stage OA before knee or hip joint replacement surgery and 55 gender-, body mass index-, age-matched controls were selected. Serum levels of c-peptide, insulin, cholesterols, OxS markers, and glucose were noted. Homeostasis model evaluation for insulin resistance was employed as the proxy measure of insulin resistance. Kellgren-Lawrence score was used to measure the radiographic severity.

As compared to the controls,  OA patients exhibited reduced total antioxidant capacity, higher oxidative stress index and total peroxide concentration. Also, the level of C-peptide found higher among OA patients than the controls. Moreover, OA radiographic severity was individually correlated with oxidised LDL and LDL-cholesterol.

This analysis explains that end-stage OA subjects have raised levels of OxS and reduced antioxidant capacity. OA is linked with dysglycemia and damaged lipid metabolism. Findings of the study emphasise on the importance of OxS and metabolic disturbances in the OA pathogenesis.