According to this study, the symptoms of depression and anxiety are more prevalent among migraine patients with interictal photophobia. Interictal photophobia could mean central sensitization due to a lengthy migraine history.

Most patients with migraine report photophobia associated with headache; a subset report interictal photophobia. These patients are light sensitive even during headache-free periods. The objective of this case–control study was to assess the prevalence of symptoms of anxiety and depression in migraine patients with and without interictal photophobia.