According to the findings of a Multicenter Osteoarthritis Study, the varus thrust is considered as one of the major risk factors for aggravating and incident knee pain. The presence of varus thrust at baseline was assessed using the video recordings of self‐paced walking trials of Multicenter Osteoarthritis Study (MOST) participants. WOMAC was used to determine the knee pain at baseline and two years.

Adjusting for the age, BMI, sex, gait speed, static knee alignment, and race, the odds of worsening meant (the either any rise in WOMAC score or clinically‐significant worsening) and knee pain was measured by applying the logistic regression. Examinations were replicated stratified by baseline radiographic OA state and amongst the subset of knees without baseline WOMAC pain.

Out of the total 3204 knees, 31.5% of knees found to have varus thrust. Knees with varus thrust had 1.37 times the odds of clinically‐important worsening WOMAC pain and 1.44 times the odds of any than to knees without thrust. The knees with thrust without baseline WOMAC pain showed 2.01 times the odds of incident total pain. As per these results, varus thrust showed a significant negative impact on knee pain and can be prevented using the non‐invasive therapies.