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Fibromyalgia
patients with structural abnormalities of small nerve fibers shows a higher
prevalence of SFP.
According to a recent study published in Seminars in Arthritis and Rheumatism, the fibromyalgia patients have high prevalence of Small fiber pathology (SPF). The information regarding SFP could be helpful in developing better pharmacotherapies and interventions for the management of fibromyalgia.
Fibromyalgia is a severe neuropathic condition that exhibits widespread chronic pain with neuropathic pain characteristics. The fibromyalgia symptoms exert a significant negative impact on patients' quality of life. Although, the pathophysiology of fibromyalgia is still not clear; evidence regarding the peripheral nervous system with a high SFP prevalence involvement in fibromyalgia is raised — this systematic literature review was intended to confirm the prevalence of SFP among patients with fibromyalgia.
EMBASE, Web of Science, CINAHL, MEDLINE, Cochrane Library and PubMed was searched for the related data. The full-text English language articles with information regarding SFP and fibromyalgia were included. Two independent reviewers screened all articles using a priori criteria. The critical appraisal tool by Munn et al. was used to assess methodological quality and related risk of bias. Random-effects meta-analysis with 95% CI was used to determine overall and subgroup pooled prevalence.
A total of 935 studies
were identified; out of which only 8 articles with 222 participants fulfil the
criteria. The pooled prevalence of SFP in fibromyalgia during the meta-analysis
noticed was 49% with average heterogeneity (I2= 68%). The prevalence rate
achieved corneal confocal microscopy was 59%, and by a skin biopsy was 45%.
Compelling evidence of a different phenotype comprising SFP in fibromyalgia was
observed during the analysis. Overall outcomes showed a high involvement of SFP
in fibromyalgia pathophysiology.
Seminars in Arthritis and Rheumatism
A Systematic Review and Meta-Analysis of the Prevalence of Small Fiber Pathology in Fibromyalgia: Implications for a new Paradigm in Fibromyalgia Etiopathogenesis
Rebecca Grayston et al.
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