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Sarcopenia not found to be the
risk factor for knee OA, but physicians should focus on weight management of
the patients as obesity and sarcopenic obesity may increase chances to develop
knee OA.
As per a recent large
longitudinal cohort study, obesity and sarcopenic obesity is related to knee
osteoarthritis. Obesity is being counted among the major risk factor of knee
osteoarthritis (KOA), measured through anthropometry. However, which type of
body composition as per muscle mass and fat is associated with KOA is still a
question. This study evaluated the individuals who were with or at the risk of
KOA. The participants selected from the
MOST (Multicenter Osteoarthritis) study were categorised into four classes;
obese, sarcopenic, sarcopenic obese and non-sarcopenic obese on the basis of
body composition from whole body DXA (Dual Energy X‐ray). By adjusting
potential confounders, the binomial regression with robust variance estimation
was used to examine baseline body composition classes association with
radiographic OA risk for 60 months.
Out of the 1653
participants with no radiographic KOA at baseline, obese (RR 2.29) and
sarcopenic obese (RR 1.91) women exhibited considerable enhanced radiographic
KOA risk. However, no men showed any association. No association was seen
between KOA and sarcopenia (women RR 0.96;
men RR 0.66). Therefore, the person with considerable KOA risk should
concentrate on weight loss strategies to reduce obesity and sarcopenic obesity.
Arthritis Rheumatol
Risk of knee OA with obesity, sarcopenic obesity and sarcopenia
Devyani Misra et al.
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