Osteoarthritis (OA) is caused by ageing joints, injury, and obesity. OA symptoms include joint pain and stiffness. The affected joint, the hand, wrist, neck, back, knee, and hip, treated by various medication and exercise and weight loss may improve OA symptoms. An association between metabolic syndrome (MeS) and osteoarthritis (OA) has been reported in recent years; however, conflicting findings have been published regarding this matter. Inhere we evaluated the relationship between different components of MeS and OA in a Fasa osteoarthritis registry (FOAS). Since 2013 The record includes all OA cases who referred to Fasa hospital (Iran). Overall, 131 patients with OA with a Kellgren & Lawrence (K&L) score >1 and 261 controls were compared. By results, the control group had MeS (P<0.001) concerned  40.8% of participants and 82.4% subjects in the OA group.   OA patients had a 6.8 (95% CI: 4.1–11.4) higher chance of acquiring MeS. Odd's ratio acquiring MeS in OA group increased to 10.9 (95% CI: 5.5–21.8) after adjusting for sex, age, and BMI.  High waist circumference (WC) has the most reliable correlation for acquiring OA (OR = 27.535, 95% CI: 6.003–126.306) for MeS.

Evaluated metabolic markers are strongly associated with OA and the addition of each component of the MeS, and increases the risk of developing OA; to control metabolic factors. And appropriate screening must be considered in health policy making and prevention programs.