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Due to potential effects on the
mechanism of cortical spreading depression and release of serotonin levels,
abnormalities in calcium levels may lead to the facilitation of migraine
attacks.
Serum levels of calcium decrease
during migraine attacks compared to healthy subjects, according to a
cross-sectional and analytical study published in the 'World Family
Medicine/Middle East Journal of Family Medicine'.
Migraine is defined as a debilitating
headache. Previous studies determined that neuromuscular disorders may be
caused due to the changes in the amount of active form of calcium and
calcium-phosphate disturbances. Therefore, this cross-sectional and analytical
study aimed to compare the ionized calcium levels in healthy subjects and
patients with headache attack.
A total of 50 patients were included and referred to Jahrom, Honari Clinic. The patients were included only if they met the criteria of the International Headache Society (IHS). Ion-Selective Electrode (ISE) method was used to determine the levels of serum ionized calcium.
About 76% of patients included in the
study were women, and the rest were men. Mean age of women was 34.8 years
whereas the mean age of men was 37 years. The mean serum levels in women with
and without migraine was 3.5 mmol/L and 4.5 mmol/L respectively. Mean serum
levels of ionized calcium in men with migraine was 3.7 mmol/L and without
migraine was 4.3 mmol/L. A significant difference in serum calcium level was
observed during migraine attacks. The serum calcium levels significantly
decreased in migraine patients as compared to healthy subjects, indicating that
calcium has an impact on migraine attacks. However, more research is needed in
this area.
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Serum level of ionized calcium in patients with migraine during a migraine attack and times without migraine
Kazemi M. et al.
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