Categories
Change Password!
Reset Password!
Despite
several significant associations, the practical utility of these biochemical
markers as predictors of anatomic bone features of knees seems limited due to
modest strength of evidences.
Modest associations were found between bone changes on imaging and biochemical markers of bone turnover, evident from a study published in the 'Arthritis Care & Research' journal. CTX-II was the marker most consistently associated with bone imaging features.
Developing a better understanding of association between biochemical markers and bone changes during imaging such as MRI features may be beneficial for a number of reasons. Therefore, Deveza, L. A and its colleagues conducted a study to determine the osteoarthritis (OA) association between biochemical markers elaborate in bone turnover and bone features on imaging in the knees.
The
evaluated data from the Foundation for the National Institutes of Health OA
Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Bone
marrow lesions (BMLs), subchondral bone area (mm2) and osteophytes and shape
(position on 3-D vector) were evaluated on magnetic resonance images, and bone
trabecular integrity (BTI) was assessed on radiographs. Serum and urinary
markers (serum C-terminal cross-linked telopeptide of type I collagen [CTX-I],
serum cross-linked N-telopeptide of type I collagen [NTX-I], urinary C-terminal and urinary NTX-I,
crosslinked telopeptide of type II collagen [CTX-II], and urinary CTX-Iα and
CTX-Iβ) were assessed. The relationship between biochemical and imaging markers
at baseline and over 24 months were evaluated using regression models adjusted
for covariates.
At
baseline, most biochemical markers were
related to BMLs, with C statistics for the presence/absence of any BML vary
from 0.675 to 0.688. Initial, urinary CTX-II was the marker most related
continuously to BMLs (with odds of having ≥5 subregions over-elaborate
differentiate to no BML increasing by 1.92-fold [95% confidence interval (95%
CI) 1.25, 2.96] per 1 SD of urinary CTX-II). Large osteophytes (odds ratio 1.39
[95% CI 1.10, 1.77]), shape (highest partial R2 = 0.032) and bone area, and
revolution in bone shape were over 24 months (partial R2 range 0.008 to 0.024).
Overall, biochemical markers were not predicting modifications in BMLs or
osteophytes, and Serum NTX-I was inversely related.
The
investigated multiple significant associations, albeit mostly weak ones. Based
on study findings, the role of systemic
biochemical markers as predictors of individual bone anatomic features of
single knees is limited.
Arthritis Care & Research
Association Between Biochemical Markers of Bone Turnover and Bone Changes on Imaging: Data From the Osteoarthritis Initiative
Leticia A. D.; et al.
Comments (0)