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Though
Oral N-Acetyl Cysteine found efficient in reducing inflammatory markers in RA
patients but, larger studies are needed to further validate and utilize these
findings to clinical practices.
According to a recent publication of the journal, Current Rheumatology Reviews the inflammatory cytokines and oxidative stress factors among rheumatoid arthritis (RA) patients were significantly reduced using oral N-Acetyl Cysteine (NAC). As the oxidative stress and inflammation play an important role in RA pathogenesis and their suppression can stop the development of the disease. NAC is a compound which comprises both anti-inflammatory and anti-oxidant properties and therefore can be used for RA treatment.
The
patients obtained either Placebo or 600 mg NAC two times a day for 12 weeks.
Measurement of Serum levels of Malondialdehyde (MDA), Total Antioxidant
Capacity (TAC), Total Oxidant Status (TOS), C-reactive Protein (CRP), nitric
oxide (NO), tumour necrosis factor-alpha (TNF-α), Erythrocyte Sedimentation
Rate (ESR), interleukin-6 (IL-6), and Total Thiol Groups (TTG) was done at
baseline and at the end of the analysis.
The
NAC group found with a significantly lower serum levels of NO, CRP, MDA, IL-6,
ESR and TNF-α than the baseline. The TTG and TAC serum levels as antioxidant
parameters also increased significantly. At the end of the study, both groups
exhibited a difference only in MDA, TTG, and NO serum levels, oral NAC showed
significant efficacy in minimizing inflammatory markers.
Current Rheumatology Reviews
Evaluating the Effects of Oral N-Acetyl Cysteine on Inflammatory and Oxidative Stress Biomarkers in Rheumatoid Arthritis
Ghazal Hashemi et al.
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