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After the success of PLT
therapy for osteoarthritis, RA patients can also benefit from this anti-inflammatory therapy.
Certain researchers have
found the significant action of platelets bound with lymphocytes in reducing
proliferation of IFN-γ and IL-17 when bound with T-lymphocytes (a type of
leukocytes). The levels of IFN-γ and IL-17 are considerably higher in patients
with rheumatoid arthritis (RA). Therefore, the lymphocytes bound with platelets
could become the promising treatment for RA.
Now to figure out the
efficiency of the combination, Carlos Zamora and colleagues conducted a research in which co-culture of
platelets with lymphocytes was done at different ratios. These platelets were
taken from different healthy persons. This showed no effect upon the
analysis. Under the presence of
stimulation, the combination decreased the production of IFN-γ, TNF-α, and
T-cell proliferation. This also decreased the expression of proteins like CD25,
PD-L1, and SLAM. However, this
co-culture enhanced the expression CD39.
Further, when platelets
were co-cultured with lymphocytes within the same compartment, researchers
observed lower levels of IFN-γ and TNF-α production and T lymphocyte
proliferation than in cultures with platelets separated from lymphocytes. When
the co-culture was blocked with anti-P-selectin Abs, the levels of IFN-γ and
TNF-α was remarkably higher than in non-blocked conditions. Also, this
co-culture in combination with synovial fluid cells from RA patients decreased
the inflammatory cytokine production and increased IL-10 production. The IL-10
is a kind of anti-inflammatory cytokine, and that helps to reduce joint inflammation.
The overall study concluded
that platelets bound with lymphocytes could control cytokines production.
Hence, the combination could be very useful to reduce the inflammatory
responses among RA patients.
The Journal of Immunology
Binding of Platelets to Lymphocytes: A Potential Anti-Inflammatory Therapy in Rheumatoid Arthritis
Carlos Zamora et al.
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