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Association of dementia risk and methotrexate amongst patients with rheumatoid arthritis

Association of dementia risk and methotrexate amongst patients with rheumatoid arthritis Association of dementia risk and methotrexate amongst patients with rheumatoid arthritis
Association of dementia risk and methotrexate amongst patients with rheumatoid arthritis Association of dementia risk and methotrexate amongst patients with rheumatoid arthritis

As explained earlier, the inflammatory processes have been shown to play a role in dementia. 

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Key take away

Adults older than 50 years of age with rheumatoid arthritis (RA), taking methotrexate (for more than 4 years) was linked with a lower risk of a following dementia diagnosis, as elucidated from this case-control study across multiple electronic health records (EHR) databases. No such association was found when sulfasalazine was used.

Background

As explained earlier, the inflammatory processes have been shown to play a role in dementia. To understand this role, the study investigators of this particular study choose 2 anti-inflammatory drugs i.e. methotrexate and sulfasalazine to examination their association with dementia risk.

Method

This is a multi-national multi-database case-control study with patients over 50 years old with RA (486 dementia cases; 641 controls), recognized from EHR in the Spain, UK, Denmark and the Netherlands. Conditional logistic regression models were used to study dementia risk.

Result

Previous methotrexate use was related with a lower risk of dementia (OR 0.71, 95% CI 0.52–0.98). Also, methotrexate therapy for >4 years portrayed a lowest risk of dementia (odds ratio 0.37, 95% CI 0.17–0.79). The use of Sulfasalazine was not related with dementia.

Conclusion

To understand the risk of dementia, there is a need of future studies to elucidate the relationship between earlier methotrexate use and duration in addition to biological treatments.

Source:

Alzheimer's Research & Therapy

Article:

Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis: a multi-national multi-database case-control study

Authors:

Danielle Newby et al.

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