EN | RU
EN | RU

Help Support

Back

Vitamin D deficiency and its influence on bone metabolism and density in a Brazilian population of healthy men

Vitamin D deficiency and its influence on bone metabolism and density in a Brazilian population of healthy men Vitamin D deficiency and its influence on bone metabolism and density in a Brazilian population of healthy men
Vitamin D deficiency and its influence on bone metabolism and density in a Brazilian population of healthy men Vitamin D deficiency and its influence on bone metabolism and density in a Brazilian population of healthy men

Vitamin D supplementation is accepted for postmenopausal women, however not for senior men, in whom osteoporosis is also usually ignored.

See All

Key take away

It is well reported in the number of studies that vitamin D deficiency results in various disorders such as secondary hyperparathyroidism, increased bone turnover, and bone loss. To date, the majority of published epidemiological studies on vitamin D deficiency refer to postmenopausal women, even those with Brazilian population. Therefore in this study, the authors evaluated the association of vitamin D deficiency and bone loss in men. The findings of this study demonstrate a high prevalence of vitamin D deficiency in a male population living in Rio de Janeiro.

Background

Vitamin D supplementation is accepted for postmenopausal women, however not for senior men, in whom osteoporosis is also usually ignored. The study intended to assess vitamin D deficiency and its connection with bone resorption, bone density, and secondary hyperparathyroidism among Brazilian men.  

Method

The selection of 120 men between20-93 years old was made and assessed the participants for 25-hydroxyvitamin D (25(OH)D), parathyroid hormone, serum calcium, biochemical markers of bone resorption (carboxy-terminal telopeptide, phosphorus, bone mineral density (dual-energy X-ray absorptiometry), creatinine, and the carboxy-terminal peptide of type I collagen). The exclusion criteria involved the medications affecting bone, glomerular filtration rate (GFR) below 30 mL/min/1.73 m2, and chronic diseases.

Result

No prior low-impact fractures were found. The 25(OH)D levels presented by the overall population were below 30 ng/mL in 46.7% and below 20 ng/mL in 27.6%. Out of 93 subjects of 50 years and older, 28 had osteoporosis. In comparison to young participants, participants of 70 years and older exhibited higher prevalence of secondary hyperparathyroidism, vitamin D deficiency, osteoporosis, high bone resorption and decreased GFR. Serum parathyroid hormone enhanced with ageing and decreasing GFR, but was not correlated with bone mineral density or 25(OH)D significantly. A notable involvement of vitamin D deficiency was seen to intensified bone resorption and osteoporosis. Bone resorption, age, identified age ≥70 years, and 25(OH)D examined by binary logistic regression model were considered as the primary determinant of osteoporosis.  

Conclusion

The male population living in Rio de Janeiro presents a high prevalence of vitamin D deficiency and the concluded data of the study emphasize its engagement on the pathogenesis of age-related bone loss.

Source:

J Clin Densitom. 2018 Jan - Mar;21(1):91-97.

Article:

Vitamin D Deficiency and Its Influence on Bone Metabolism and Density in a Brazilian Population of Healthy Men.

Authors:

Moreira ML et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en
Try: