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Use of ketamine- propofol versus sodium thiopental-fentanyl in sedation

Use of ketamine- propofol versus sodium thiopental-fentanyl in sedation Use of ketamine- propofol versus sodium thiopental-fentanyl in sedation
Use of ketamine- propofol versus sodium thiopental-fentanyl in sedation Use of ketamine- propofol versus sodium thiopental-fentanyl in sedation

This randomised double-blind study aimed to evaluate the efficacy of sodium thiopental-fentanyl (TF) with ketamine-propofol (KP) for procedural sedation and analgesia in the emergency department.

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Key take away

In this study, strong muscle relaxation of sodium thiopental and very brief sedative effects of this medication was the positive hypotheses to compare this medicine with ketofol. Although both combinations of KP and TF were found effective with no noteworthy complication. But, sodium thiopental offered more desirable post-sedation analgesia, reduced agitation and very transitory sedative effects.

Background

This randomised double-blind study aimed to evaluate the efficacy of sodium thiopental-fentanyl (TF) with ketamine-propofol (KP) for procedural sedation and analgesia in the emergency department.

Method

The patients were subjected to receive either KP (47 patients) or TF (49 patients) for desired sedation level. A comparison of respiratory and haemodynamic issues, recovery agitation, patient and physician satisfaction, recall of painful procedure, nausea and vomiting were done.

Result

The mean and SD scores patients' and physicians’ satisfaction performing the procedures in TF and KP groups were almost similar. Patient recalled was detected in 39 (79.59%) and 18 (38.29%) of patients in the TF and KP groups, respectively. About 2.1% and 8.1% in the KP and TF groups reported transient hypoxia.

It lead to 4.2% versus 8.1% airway manoeuvres being accomplished in KP and TF groups, without the requirement for endotracheal intubation or additional admission. A detail of the results has been mentioned in the following Table 1:


Table 1: Efficacy and adverse effects of Sodium thiopental–fentanyl and Ketamine–propofol groups

Source:

Emergency Medicine Journal: EMJ

Article:

Comparison of the efficacy of ketamine- propofol versus sodium thiopental-fentanyl in sedation: a randomised clinical trial

Authors:

Maryam Bahreini et al.

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