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A prospective diagnostic study was carried out to study the clinical efficacy of F-18 NaF PET/CT for the evaluation of disease activity in RA patients.
The joints with synovitis had notably greater F-18 sodium fluoride (NaF) uptake as compared to
those with no synovitis in rheumatoid arthritis (RA) patients. Therefore, the
use of F-18 NaF positron
emission tomography/computed tomography (PET/CT) as an imaging tool to
analyze the disease activity might be useful in RA patients.
A prospective diagnostic study was carried out to
study the clinical efficacy
of F-18 NaF
PET/CT for the evaluation
of disease activity in RA patients.
The study incorporated 17 people with RA. These patients went through F-18 NaF PET/CT apart from the physical checkup, blood test, and ultrasonography. The joint SUV and joint-to-bone uptake ratio were calculated for each of the 28 tender joints included in estimating the DAS28-ESR i.e. the disease activity score via erythrocyte sedimentation rate.
Association
between PET/CT and clinical factors and the prognostic values of PET/CT factors
for high disease activity and joints with synovitis were assessed.
Tender joints and both tender plus swollen joints had a considerably greater ratio of joint SUV and joint-to-bone uptake as compared to the joints with no synovitis, as shown in the following table:
The
total joint and summed joint-to-bone uptake ratio of 28 joints revealed a
strong positive
association with DAS28-ESR. The summed joint SUV displayed significant positive
correlations with ultrasonography outcomes.
For joint SUV, the
sensitivity for predicting synovitis was 83.2% and specificity was 92.7% while
for joint-to-bone uptake ratio, sensitivity and specificity were 81.5% and
90.7% respectively. The aggregate of both PET/CT constraints of 28 joints
revealed 100% diagnostic accuracy for the likelihood of high disease activity
in RA.
The total joint uptake portrayed a strong positive relationship with DAS28-ESR and
precisely projected the high disease activity.
Quantitative Imaging in Medicine and Surgery
Clinical utility of F-18 sodium fluoride PET/CT for estimating disease activity in patients with rheumatoid arthritis
Hee Jin Park et al.
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