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Understanding role of chemokines as valuable markers for diabetic polyneuropathy

Understanding role of chemokines as valuable markers for diabetic polyneuropathy Understanding role of chemokines as valuable markers for diabetic polyneuropathy
Understanding role of chemokines as valuable markers for diabetic polyneuropathy Understanding role of chemokines as valuable markers for diabetic polyneuropathy

Earlier studies have depicted the function of chemokines in the progress of neuropathy and neuropathic pain disorders. This pilot study aimed to investigate the link between plasma concentrations of chemokines (CXCL9, CXCL10, and CXCL11) and the incidence of diabetic peripheral neuropathy (DPN) in diabetic patients.

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Key take away

CXCL10 levels could be used as a significant marker for early discovery and application of therapeutic approaches to recover from and/or prevent diabetic peripheral neuropathy.

Background

Earlier studies have depicted the function of chemokines in the progress of neuropathy and neuropathic pain disorders. This pilot study aimed to investigate the link between plasma concentrations of chemokines (CXCL9, CXCL10, and CXCL11) and the incidence of diabetic peripheral neuropathy (DPN) in diabetic patients.

Method

Overall, 73 diabetic patients were studied. Thirty-six of these patients had DPN and 37 were without DPN. The Semmes-Weinstein test was used to determine DPN. The Duoset ELISA kits were used to determine the plasma levels of circulating chemokines.

Result

CXCL10 levels were considerably elevated in individuals having DPN compared to individuals without DPN. Although not statistically significant, the serum levels of CXCL9 were also greater in DPN patients, as shown in Table 1: 


Conclusion

Enhanced circulating levels of CXCL10 were found to be linked with DPN, proposing a role of this particular chemokine in the development of DPN.

Source:

International Journal of Clinical Practice

Article:

Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes

Authors:

Pilar Ascaso et al.

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