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A randomized, triple-blind, single-center, split-mouth clinical study was performed to determine the pain-relieving effect of 400 mg ibuprofen administered 30 minutes prior to or immediately after third molars surgery under local anesthesia.
Compared to presurgery
administration, ibuprofen administration immediately after third molar surgery
is more effective.
A
randomized, triple-blind, single-center, split-mouth clinical study was
performed to determine the pain-relieving effect of 400 mg ibuprofen
administered 30 minutes prior to or immediately after third molars surgery
under local anesthesia.
In
this study, 38 patients for a total of 76 bilateral symmetrical fully bone
impacted mandibular third molars were included. Each participant underwent
separate surgical sessions for the right and left sides. Ibuprofen was given
randomly 30 minutes prior to or immediately post-intervention. Estimation of
pain intensity utilizing Numerical Rating Scale-11, the timing of rescue
treatment consumption, and overall tablets intake over 3 days was done.
Overall pain intensity score reduced in the
cohort treated with ibuprofen immediately after (3.13 ± 2.46) compared to
before (3.58 ± 2.40) surgery, with substantial differences only on the third
and second day. The mean time to the first utilizing rescue treatment was found
to be longer in postsurgery (598.33 ±
422.62 minutes) compared to the presurgery (406.25 ± 149.79 minutes) analgesic
therapy group. Both the cohorts illustrated a similar number of supplemented
ibuprofen tablets.
In patients undergoing third molar
surgery, ibuprofen should be administered immediately after the oral surgery.
Oral Diseases
Effects of ibuprofen administration timing on oral surgery pain: A randomized clinical trial
Gerardo La Monaca et al.
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