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Relationship between neuropathic pain and obesity

Relationship between neuropathic pain and obesity Relationship between neuropathic pain and obesity
Relationship between neuropathic pain and obesity Relationship between neuropathic pain and obesity

Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain.

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Key take away

Obesity is a risk factor for musculoskeletal system disorders like neck pain, osteoarthritis and low back pain. This study efficiently depicted that obesity-induced systemic inflammation can fortify the paroxysmal and negative symptoms of neuropathic pain. It may worsen the neuropathic pain intensity and impair the nerve damage.

Background

Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain. This was conducted to determine if obesity affects neuropathic pain, usually considered unrelated to the weight-load on the musculoskeletal system.

Method

Using a cut-off body mass index value of 25, 44 patients with neuropathic pain were grouped into a “high-BMI” group and a “normal-BMI” group.

Result

The numeric rating scale of the high-BMI group was significantly higher than that of the normal-weight group (p <0.05). The total NPSI scores were significantly higher (p <0.01), and the paroxysmal pain and the negative symptoms were more serious in the high-BMI group than in the normal-BMI group. The high-BMI subjects also had significantly higher SF-MPQ scores (p <0.05). However, both physical and mental health status on the SF-36 were comparable between the groups.

Conclusion

Neuropathic pain that did not arise from musculoskeletal damage was higher in the high-BMI patients. Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation. These findings should have needed to be confirmed in future studies.

Source:

Pain Research and Management 2016

Article:

Relationship between Neuropathic Pain and Obesity

Authors:

Jun Hozumi et al.

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