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Study evaluates link between cardiovascular risk factors and death in hospitalized COVID-19 patients

Study evaluates link between cardiovascular risk factors and death in hospitalized COVID-19 patients Study evaluates link between cardiovascular risk factors and death in hospitalized COVID-19 patients
Study evaluates link between cardiovascular risk factors and death in hospitalized COVID-19 patients Study evaluates link between cardiovascular risk factors and death in hospitalized COVID-19 patients

A meta-analysis and systematic review were performed to explore the relationship between cardiovascular risk factors and in-hospital death in subjects suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Key take away

In coronavirus disease 2019 (COVID-19) patients, diabetes, and older age are linked with a greater risk of in-hospital death. Male gender, smoking, and hypertension were not independently linked with adverse and fatal outcomes.

Background

A meta-analysis and systematic review were performed to explore the relationship between cardiovascular risk factors and in-hospital death in subjects suffering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Method

Databases like SCOPUS, Cochrane, Web of Sciences, and MEDLINE were explored for prospective or retrospective observational studies reporting data on death and cardiovascular risk factors in coronavirus-infected subjects. To determine the link between cardiovascular risk factors and the incidence of death during hospitalization, the univariable and multivariable age-adjusted assessments were performed. The analysis incorporated 45 studies recruiting 18,300 participants. The incidence of death during hospitalization was the major outcome.

Result

Pooled estimate of in-hospital death was 12%. The univariable meta-regression analysis illustrated a substantial link between age (coefficient: 1.06), diabetes (coefficient: 1.04), and hypertension (coefficient: 1.01) with in-hospital mortality.

Smoking and the male gender did not considerably impact mortality. At multivariable meta-regression assessment, diabetes was considerably linked with mortality during hospitalization (coefficient: 1.02). Hypertension was found to be no longer vital after adjusting for age (coefficient: 1.00). In all the multivariable models, a vital link between age and in-hospital death was witnessed.

Conclusion

Diabetes and older age can elevate the risk of in-hospital death. Male gender, smoking, and hypertension are not independently associated with adverse outcomes.

Source:

BMC Cardiovascular Disorders

Article:

Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients

Authors:

Angelo Silverio et al.

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