EN | RU
EN | RU

Help Support

Back

Study evaluates efficacy of novel sequential treatment regimen containing bismuth to treat H. pylori

Study evaluates efficacy of novel sequential treatment regimen containing bismuth to treat H. pylori Study evaluates efficacy of novel sequential treatment regimen containing bismuth to treat H. pylori
Study evaluates efficacy of novel sequential treatment regimen containing bismuth to treat H. pylori Study evaluates efficacy of novel sequential treatment regimen containing bismuth to treat H. pylori

A retrospective study was conducted to explore whether the new sequential therapy containing bismuth is effective to treat H.pylori infection in children.

See All

Key take away

A new sequential therapy including bismuth for 14 days can be used as first-line therapy in children as it offers a high rate of Helicobacter pylori (H. pylori) elimination.

Background

A retrospective study was conducted to explore whether the new sequential therapy containing bismuth is effective to treat H.pylori infection in children.

Method

In this study, 75 patients (more than eight years of age, mean age 15.1 ± 2.4 years) suffering from H. pylori gastritis were included. As per Rome IV criteria, 38 subjects had dyspepsia and functional abdominal pain, and 37 subjects had alarm findings depicting organic disease.

Participants were treated with a new sequential therapy consisting of lansoprazole, amoxicillin for seven days. This was subsequently followed by lansoprazole, metronidazole, tetracycline, and bismuth subsalicylate. The eradication status was estimated by the H. pylori stool antigen test eight weeks after completion of the therapy.

Result

No participant discontinued treatment due to adverse effects. All participants had antral gastritis (76.0%) or pangastritis (24.0%). The peptic ulcer rate was about 6.6%. Eradication therapy was administered to all patients with or without peptic ulcer. The elimination of H pylori eradication was attained in 69 (92.0%) patients and symptoms improved in 61 (81%) of those eradicated patients.

Conclusion

In children, a new sequential therapy including bismuth for 14 days is a promising therapeutic approach to treat H. pylori infection.

Source:

Helicobacter

Article:

Efficacy of a novel sequential treatment regimen containing bismuth for Helicobacter pylori eradication in Turkish children

Authors:

Melike Arslan et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru ua
Try: