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Role of Pioglitazone in slowing Alzheimer's disease progression

Alzheimer's disease Alzheimer's disease
Alzheimer's disease Alzheimer's disease

This systematic review and meta-analysis ascertained Pioglitazone's effectiveness and safety in enhancing cognitive function in Alzheimer's disease.

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Key take away

Pioglitazone offers a safe therapeutic avenue with promising prospects for mitigating the advancement of mild-to-moderate Alzheimer's disease.

Background

This systematic review and meta-analysis ascertained Pioglitazone's effectiveness and safety in enhancing cognitive function in Alzheimer's disease.

Method

Publications from the past 12 years were identified from databases including Cochrane Central, Scopus, PubMed, and other trial registries. Those studies that investigated Pioglitazone (15-30 mg) with other oral hypoglycemic agents, diabetic diet, or placebo over a duration of at least six months were included. Overall, 525 records were screened, resulting in the inclusion of 5 studies for quantitative assessment. Extraction of data was carried out utilizing a pretested form. Utilizing Cochrane's risk of bias assessment tool, this was followed by a risk of bias assessment.

Result

In Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores, Pioglitazone did not exhibit a substantial betterment [mean difference (MD): -1.16; 95% confidence interval (CI): -4.14-1.81]. However, sensitivity analysis, excluding 1 study, revealed pivotal efficacy [MD: -2.75; 95% CI: -4.84--0.66]. In the Pioglitazone arm, the Wechsler Memory Scale-Revised logical memory I (WMS-R) scores illustrated a remarkable betterment [MD: 2.02; 95% CI: 0.09-3.95].

Conclusion

Pioglitazone represents a safe intervention and holds promise in attenuating the progression of Alzheimer's disease.

Source:

Neurology India

Article:

Drug Repositioning of Pioglitazone in Management and Improving the Cognitive Function among the Patients With Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis

Authors:

Roopa S Basutkar et al.

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