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A study was carried to investigate the efficacy of rabeprazole (20 mg) vs. omeprazole (40 mg) in the triple therapy regimen.
In acid-peptic disorder patients
having Helicobacter pylori (H. pylori) infection, rabeprazole has comparable H.
pylori elimination rates in comparison with omeprazole when co-administered
with the antibiotics like clarithromycin and amoxicillin for about two weeks.
A
study was carried to investigate the efficacy of rabeprazole (20 mg) vs.
omeprazole (40 mg) in the triple therapy regimen.
Overall, 100 H.pylori-infected
patients who gave their consent for trial participation were incorporated. In
total, 50 subjects were given omeprazole-based triple treatment and the other
50 subjects were given rabeprazole-based triple treatment. Following two weeks
of triple therapy and four weeks of proton pump inhibitor therapy, H. pylori
antigen was tested in stools.
A
substantial correlation was noted
between nausea, epigastric pain, and water brash with a p-value, 0.001.
Similarly, the p-value was < 0.05 between bile reflux, hiatus hernia, and
reflux and the p-value was < 0.001 among hiatus hernia and reflux. In the
follow-up assessment, after triple therapy, H. pylori antigen tests were found
to be negative in about 94% of the trial population, who were administered
rabeprazole which displayed similarity to omeprazole-recipients (92%).
Both
rabeprazole and omeprazole have comparable H. pylori elimination rates when
co-administered with antibiotics like clarithromycin and amoxicillin for two
weeks.
Journal of Nepal Health Research Council
Comparative Study on Effect of Rabeprazole Versus Omeprazole in Acid-peptic Disorder with Helicobacter pylori Infection
Sukh Bahadur Gurung et al.
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