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Oral versus transdermal patch of Diclofenac for post endodontic pain relief

Endodontic pain relief Endodontic pain relief
Endodontic pain relief Endodontic pain relief

To establish the effectiveness of pre-treatment with Diclofenac in managing post-endodontic pain while comparing two modes of delivery i.e. oral, and transdermal patch.

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Key take away

Compared to oral delivery, transdermal Diclofenac patches are a preferred choice in patients with post-endodontic pain due to their safety, effectiveness, and several advantages in delivering drugs to the systemic circulation including enhanced bioavailability.

Background

To establish the effectiveness of pre-treatment with Diclofenac in managing post-endodontic pain while comparing two modes of delivery i.e. oral, and transdermal patch.

Method

This randomized controlled trial comprised 180 patients aged 18 to 65 years with irreversible pulpitis. The patients were divided into 3 groups:

GROUP A (Control group): Patients were administered only an over-the-counter pain reliever (Acetaminophen) as a rescue medication.

GROUP B (Oral Diclofenac group): Patients received Diclofenac tablets orally immediately prior to undergoing root canal treatment.

GROUP C (Transdermal Diclofenac patch group): Patients received a transdermal patch of Diclofenac shortly before undergoing root canal treatment.

Using visual analog scale (VAS), the pain was examined.

Result

In each of the three groups, the frequency of pain was evaluated at intervals of the first 4 hours, 8 hours, 12 hours, 24 hours, and 48 hours after the surgery. With statistically significant p values, the transdermal Diclofenac patch appears to be a promising analgesic therapy to relieve endodontic pain.

Conclusion

Preoperative analgesics are crucial in minimizing post-endodontic pain, and the use of transdermal patches containing Diclofenac proved to have promising results for the same.

Source:

Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery

Article:

Comparative Evaluation of the Efficacy of Two Modes of Delivery of Diclofenac for The Management of Post Endodontic Pain- A Randomized Controlled Clinical Trial

Authors:

Dr. Atul Anand Bajoria et al.

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