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A prospective study was carried to explore efficacy of gastroesophageal reflux disease (GERD) therapy in mitigating asthma in poorly controlled asthmatic children.
In children suffering from asthma,
there is an increased prevalence of GERD. Omeprazole in sufficient doses was
found to improve the control of asthma.
A
prospective study was carried to explore efficacy of gastroesophageal reflux
disease (GERD) therapy in mitigating asthma in poorly controlled asthmatic
children.
The study recruited 102 asthmatic children (age 4 to 16 years). Utilizing pH monitoring, the presence of acid reflux was checked. In total, 59 (57.8%) participants had acid reflux. GERD subjects were randomized to either the omeprazole group that received omeprazole for 6 months or the control group that did not receive any treatment.
The score of children asthma control test after
six months was the study's endpoint. With the help of pH monitoring, the acid
suppression was checked at the end of therapy. Following therapy, children
having persistent acid reflux were given high doses of proton-pump inhibitors
(PPI) and therefore were again reassessed six months later.
GERD was considerably more common in boys. Administration of omeprazole in sufficient doses was found to improve the management of asthma in five children out of six (84.8 vs 11.5). Three factors such as male gender, normal birth weight, and a positive prick-test were statistically linked with asthma control improvement after PPI treatment.
In the
multivariate assessment, these factors were not satisfactorily precise or were
not confirmed. The probability of a causal relationship between asthma and acid
reflux, troublesome to highlight with pH monitoring, was found to be poor.
Omeprazole effectively controls asthma in
asthmatic children having GERD, thus,
indicating the possible advantage of an efficient GERD therapy in improving
asthma control.
The Journal of asthma
Does omeprazole improve asthma-control in poorly-controlled asthmatic child
Abdelghani Yagoubi et al.
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