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To determine the non‐steroidal anti‐inflammatory drugs (NSAIDs) effectiveness and adverse effects that treat cancer‐related pain among children and adolescents in any setting.
Non-steroidal anti-inflammatory drugs (NSAIDs)
are common drugs that exhibits analgesic and anti-inflammatory effects. They
are widely used in treatment of pain and fever in adults as well as pediatric
population. It is a Cochrane review study that analysed different randomized
double blind controlled trials to assess the effects of NSAIDs in children
suffering from chronic pain and evaluated that there are limited RCTs in
history related to this context.
To determine the non‐steroidal anti‐inflammatory drugs
(NSAIDs) effectiveness and adverse
effects that treat cancer‐related pain among children and adolescents in any
setting.
MEDLINE, CENTRAL, and Embase were searched from inception
to 21 February 2017 for collecting associated data. The reference lists of
retrieved studies and reviews along with online clinical trial registries were
also explored. The assessment of studies for eligibility was done by two
authors independently. The dichotomous data was used to estimate the risk ratio
and number needed to operate for one further event, using standard methods. The
evaluation of GRADE was done and planned to design a 'Summary of findings'
table.
No studies were suitable for inclusion. Investigators
demoted the quality of evidence by three levels due to the shortage of data
listed for any outcome.
No evidence was reported that NSAIDs could decrease cancer‐related
pain among children and adolescents.
Cochrane Database of Systematic Reviews 2017
Non-steroidal anti-inflammatory drugs (NSAIDs) for cancer-related pain in children and adolescents.
Tess E Cooper et al.
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