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This study aimed to describe the neurologic features in PIMS-TS.
In the quest to find neurologic symptoms in pediatric
inflammatory multisystem syndrome temporally linked with SARS-CoV-2 (PIMS-TS),
the children with neurologic symptoms had notably higher markers of systemic
inflammation, as revealed from this single-center retrospective observational
study.
This study aimed to describe the neurologic features in
PIMS-TS.
A total of 75 children (mean age of 7.9 years) with PIMS-TS
were identified. A retrospective review was perfomed to assess the clinical and
investigative characteristics together with short-term consequences of children
with neurologic symptoms.
Nine children (12%) were found to have neurologic presentations as shown below:
Cranial images abnormalities was observed in 4 children.
After 3 months, 4 children had complete recovery, 1 had unilateral paresis, 3 had behavioral changes, and 1 child
deceased. Children with neurologic connection had greater systemic inflammatory
and prothrombotic markers. These markers were greater in those who did not
completely recover at 3 months.
Similar risk factors for PIMS-TS was observed in children
with and no neurologic connection.
About 12% patients with PIMS-TS displayed wide neurologic
characteristics. Half of these children had full recovery with no neurologic
damage at 3 months. Children with neurologic connection and in those who did
not recover fully had considerably greater systemic inflammatory markers.
Neurology(R) neuroimmunology & neuroinflammation
Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2
Mario Sa et al.
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