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This systematic review and meta-analysis examined the effectiveness of magnesium sulphate in preventing peri-operative laryngospasm (a potentially life-threatening condition) in pediatric patients undergoing non-cardiac surgery.
Magnesium may help prevent laryngospasm in pediatric patients undergoing under general anesthesia, with local administration reducing its incidence.
This systematic review and meta-analysis examined the effectiveness of magnesium sulphate in preventing peri-operative laryngospasm (a potentially life-threatening condition) in pediatric patients undergoing non-cardiac surgery.
A trial registry and four databases were searched for pediatric patients undergoing general anesthesia, with cardiopulmonary bypass patients excluded. The study compared the peri-operative administration of magnesium sulphate to placebo or other pharmacological agents, focusing on the incidence of laryngospasm, and conducted a meta-analysis and sub-group analysis.
The study involved 953 participants from 13 studies and found that magnesium administration significantly reduced laryngospasm rates by 6% (Odds ratio [OR] 0.48 [95% CI 0.25-0.96], p = 0.04) when compared to the control group. Subgroup assessment illustrated a 12.5% lower laryngospasm rate (OR 0.26 [CI 0.09-0.76], p = 0.01) in the local magnesium group. However, in studies using simply intravenous magnesium, no discernible variation was seen in the incidence of laryngospasm.
Magnesium administration may be a potential treatment option for laryngospasm. However, intravenous magnesium's effectiveness in preventing laryngospasm must be further investigated.
Anaesthesia Critical Care & Pain Medicine
The efficacy of magnesium sulphate in preventing laryngospasm in paediatric patients undergoing general anaesthesia: A systematic review and meta-analysis of randomised control trials
Mohammad Ahmed Rasheed et al.
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