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Improving pediatric vitiligo management: Efficacy of Tacrolimus + 308-nm excimer lamp

Pediatric vitiligo management Pediatric vitiligo management
Pediatric vitiligo management Pediatric vitiligo management

The safety and effectiveness of integrating the 308-nm Excimer lamp with Tacrolimus 0.1% ointment was examined in comparison to using Tacrolimus 0.1% ointment alone for tackling vitiligo in kids.

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Key take away

Pediatric vitiligo patients treated with Tacrolimus in conjunction with the 308-nm excimer lamp show better repigmentation outcomes than those treated solely with Tacrolimus.

Background

The safety and effectiveness of integrating the 308-nm Excimer lamp with Tacrolimus 0.1% ointment was examined in comparison to using Tacrolimus 0.1% ointment alone for tackling vitiligo in kids.

Method

Overall, 50 vitiligo (affecting <10% of the body surface area) pediatrics were randomly segregated into two groups. Group A was given Tacrolimus 0.1% ointment twice daily along with 308-nm Excimer light treatment twice weekly. Contrarily, Group B was managed solely with Tacrolimus 0.1% ointment twice daily. At 30, 90, and 180 days, repigmentation percentages were assessed utilizing the rule of nine.

Result

Group A demonstrated remarkable improvement in repigmentation, escalating from 10% at one month to 65% at six months. Conversely, Group B experienced a rise from 10% to 30% during a similar period. Group A exhibited considerably higher therapeutic efficiency at both the 3-month and 6-month follow-up intervals (p-value < .001). Furthermore, Group A attained notably superior repigmentation rates in the lower limb, trunk, and facial areas. Minimal side effects were observed,

Conclusion

In pediatrics suffering from vitiligo, combining Tacrolimus (calcineurin inhibitor) with the 308-nm excimer lamp led to better repigmentation outcomes as opposed to Tacrolimus monotherapy. This combined therapeutic approach may present a promising and safe novel treatment regimen for pediatric vitiligo.

Source:

Journal of Dermatological Treatment

Article:

Efficacy and safety of 308-nm Excimer lamp combined with Tacrolimus 0.1% ointment vs Tacrolimus 0.1% ointment as monotherapy in treating children with limited vitiligo: a randomized controlled trial

Authors:

Diala Alshiyab et al.

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