EN | RU
EN | RU

Help Support

Back

GERD and CRS: A Mendelian randomization investigation of causal association

GERD and Rhinosinusitis GERD and Rhinosinusitis
GERD and Rhinosinusitis GERD and Rhinosinusitis

Utilizing a two-sample Mendelian randomization analysis, this study investigated the potential link between chronic rhinosinusitis (CRS) and gastroesophageal reflux disease (GERD)

See All

Key take away

GERD is associated with a higher risk of chronic rhinosinusitis, and asthma mediates this relationship, suggesting GERD's contribution to unified airway disease.

Background

Utilizing a two-sample Mendelian randomization analysis, this study investigated the potential link between chronic rhinosinusitis (CRS) and gastroesophageal reflux disease (GERD)

Method

Leveraging genome-wide association studies (GWAS), researchers conducted a univariable Mendelian randomization to probe the causal link between GERD and CRS. Instrumental variables related to anti-GERD treatment were employed for validation. The primary Mendelian randomization analysis utilized an inverse variance weighted (IVW) method, complemented by multiple sensitivity analyses.

Subsequently, a multivariable Mendelian randomization was performed to adjust for potential confounders, establishing a direct GERD-CRS relationship. Lastly, a network Mendelian randomization analysis was undertaken to shed light on asthma's mediating role in the GERD-CRS connection.

Result

The findings of the univariable Mendelian randomization revealed a link between GERD and a heightened CRS risk (IVW Odds ratio [OR] = 1.30, 95% Confidence Interval [CI] = 1.18-1.45, p = 4.19 × 10-7 ). As found, Omeprazole usage was related to a reduced CRS risk (IVW OR = 0.64, 95% CI = 0.42-0.98, p = 0.039). Even after adjusting for potential confounders such as allergic rhinitis, smoking habits, asthma, and body mass index in the multivariable Mendelian randomization, the GERD-CRS causal connection persisted. Moreover, asthma was found to mediate 19.65% (95% CI = 2.69%-36.62%) of the causal effect of GERD on CRS.

Conclusion

GERD exhibited an independent connection with an elevated CRS risk. The mediation of asthma in the GERD-CRS relationship suggested GERD as one of the mechanisms contributing to unified airway ailment.

Source:

Laryngoscope

Article:

Gastroesophageal Reflux and Chronic Rhinosinusitis: A Mendelian Randomization Study

Authors:

Tao Guo et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru ua
Try: