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To examine sequential therapy used for 14 days and antibiotic resistance of H. Pylori eradication in children.
Pediatric Helicobacter pylori infection is one of the
most commonly leads to peptic ulcer. As concluded from the outcomes of this
double-blinded randomized controlled trial, the
use of sequential therapy for 2 weeks can be an effective first-line
treatment for Helicobacter pylori eradication in pediatrics.
To examine sequential therapy used for 14 days and antibiotic
resistance of H. Pylori eradication in children.
A total of 87 children (mean age 13.5 years; 55 males) with H.
pylori infection were enrolled in this study. The patients who were either
triple therapy for 7 days (25 patients, 28.7%)
or 14 days (24 patients, 27.6%), or
sequential therapy for 14 days (38 patients, 43.7%)
were investigated.
The use of sequential therapy for 14 days was significantly
better to 7-day triple therapy (97.4% vs. 80%), and was better than triple
therapy for 14 days (83%). Resistant rate of clarithromycin was 22.2%,
metronidazole was 16.7%, levofloxacin was 16.7%, and amoxicillin was 2.2% out
of 54 patients with presented antibiotic resistance data. Clarithromycin
resistance and eradication success were inversely related.
Sequential therapy for 14 days is superior to triple
therapy, with a high eradication rate (>90%) in an area of high
clarithromycin resistance in children with H.pylori infection.
Journal of the Formosan Medical Association
Fourteen-day sequential therapy is superior to 7-day triple therapy as first-line regimen for Helicobacter pylori infected children
Da-Jyun Su et al.
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