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Efficacy of tailored H. pylori eradication vs. modified bismuth quadruple therapy

Helicobacter pylori Helicobacter pylori
Helicobacter pylori Helicobacter pylori

This study was carried out to evaluate the overall efficacy of two therapies: personalized Helicobacter pylori (H.pylori) eradication and modified bismuth-containing quadruple treatment.

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Key take away

This study comprising of 282 patients infected with H. pylori found the use of PAM-B therapy to be similar in effectiveness but was more cost-effective as compared to the standard treatment as per the outcomes of DPO-PCR tests.

Background

This study was carried out to evaluate the overall efficacy of two therapies: personalized Helicobacter pylori (H.pylori) eradication and modified bismuth-containing quadruple treatment.

Method

In this randomized controlled trial, a rapid urease test or dual priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) test was used to diagnose H. pylori infection. Patients were divided into 2 groups, namely: Tailored therapy (TT) and PAM-B groups with 141 patients in each group:

TT group: Standard triple or typical bismuth quadruple therapy

PAM-B therapy: Pantoprazole 40 mg, amoxicillin 1000 mg, metronidazole 750 mg, and bismuth subcitrate 600 mg two times per day for 2 weeks.

Result

H. pylori eradication rate did not vary considerably as per the intention-to-treat, modified intention-to-treat, and per-protocol analyses. TT group had a greater average cost for successful eradication compared to the PAM-B group, as shown in Table 1:

Conclusion

PAM-B therapy demonstrated similar efficacy and better cost-effectiveness than TT.

Source:

Expert Review of Anti-infective Therapy

Article:

Comparison of tailored Helicobacter pylori eradication versus modified bismuth quadruple therapy in Korea: a randomized controlled trial

Authors:

Jun-Hyung Cho et al.

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