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A retrospective trial aimed to determine efficacy of the combination of paravertebral injection of recombinant human interferon-α2b and dorsal root ganglion (DRG) pulsed radiofrequency to treat individuals having neuralgia and its preventive efficacy on postherpetic neuralgia.
For acute stage herpes zoster neuralgia, the combination of
recombinant human interferon-α2b and radiofrequency is an effective therapeutic
approach and can prevent the occurrence rate of postherpetic neuralgia.
A retrospective trial aimed to
determine efficacy of the combination of paravertebral injection of recombinant
human interferon-α2b and dorsal root ganglion (DRG) pulsed radiofrequency to
treat individuals having neuralgia and its preventive efficacy on postherpetic
neuralgia.
The recruited patients (n=62) were segregated into (i) Group A (n=31): Received pulsed radiofrequency paraspinal injection of recombinant human interferon-α2b, and (ii) Group B (n=31): Received combo of pulsed radiofrequency and paravertebral saline injection. For assessing pain, the numerical rating scales (NRS) scores were utilized.
Recording of the dose of the
analgesic drug was done. The levels of galectin-3 and interleukin-6 levels in
blood were evaluated between the two arms prior to therapy and at weeks one,
two, and four after therapy. The postherpetic neuralgia incidence was examined
in both groups.
Following therapy, a decline in levels of galectin-3 and interleukin-6 in blood, pain, and the dosage of oral administration of morphine and gabapentin capsules were witnessed in all participants. In comparison with Group B, subjects in Group A had reduced NRS scores as shown below:
After
therapy, a decline in blood levels of galectin-3 and interleukin-6, and
reduction in dosages of oral gabapentin capsules and morphine hydrochloride
immediate-release tablets was noted in Group A vs. Group B. The occurrence of
postherpetic neuralgia was considerably diminished at eight and 12 weeks.
Combination of DRG pulsed
radiofrequency and paravertebral injection of recombinant interferon α2b is an
effective therapy for acute herpes zoster neuralgia, and can effectively
prevent the occurrence of postherpetic neuralgia.
The Journal of Pain Research
Efficacy of Dorsal Root Ganglion Pulsed Radiofrequency Combined with Paravertebral Injection of Recombinant Human Interferon-α2b in Herpetic Neuralgia
Yong Fei et al.
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