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This prospective trial aimed to determine the safety and efficacy of a single intraarticular injection of platelet-rich plasma for individuals suffering from symptomatic ankle osteoarthritis.
A single intraarticular injection
of platelet-rich plasma seems beneficial to manage patients suffering from
ankle osteoarthritis as it improves pain and physical function.
This
prospective trial aimed to determine the safety and efficacy of a single
intraarticular injection of platelet-rich plasma for individuals suffering from
symptomatic ankle osteoarthritis.
The
study enrolled 44 individuals suffering from symptomatic ankle osteoarthritis
for at least six months. Participants were given a single injection of
platelet-rich plasma (3 ml) into the
affected ankles. Alteration in the visual analog scale (VAS) pain at six months
from the baseline was the major endpoint. The secondary endpoints incorporated:
(i) Single-leg stance test (SLS), (ii) American Orthopedic Foot and Ankle
Society (AOFAS) hindfoot-ankle score, (iii) the Ankle Osteoarthritis Scale
(AOS) score, (iv) rescue analgesics intake, and (v) patient satisfaction. In
total, 39 participants (88.64%) fulfilled the trial.
The AOS and VAS substantially improved at one, three, and six-months. At one, three, and six months, the mean VAS pain considerably declined while the mean AOFAS hindfoot-ankle score improved from baseline (baseline VAS 4.1 ± 1.7, baseline mean AOFAS hindfoot-ankle score 80.3) The mean total AOS score reduced from baseline postinjection. At each follow-up, the SLS tests considerably improved. Acetaminophen intake dropped considerably and no severe adverse events were found to occur.
To manage ankle osteoarthritis
patients, a single intraarticular injection of platelet-rich plasma may be
used.
The Journal of Foot & Ankle Surgery
Efficacy and Safety of a Single Intra-articular Injection of Platelet-rich Plasma on Pain and Physical Function in Patients With Ankle Osteoarthritis-A Prospective Study
Shu-Fen Sun et al.
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