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Effectiveness of Pregabalin for treating diabetic peripheral neuropathy pain in type 1 or type 2 diabetes mellitus patients

Effectiveness of Pregabalin for treating diabetic peripheral neuropathy pain in type 1 or type 2 diabetes mellitus patients Effectiveness of Pregabalin for treating diabetic peripheral neuropathy pain in type 1 or type 2 diabetes mellitus patients
Effectiveness of Pregabalin for treating diabetic peripheral neuropathy pain in type 1 or type 2 diabetes mellitus patients Effectiveness of Pregabalin for treating diabetic peripheral neuropathy pain in type 1 or type 2 diabetes mellitus patients

The study aimed to compare the Pregabalin safety and efficacy in concern to painful diabetic peripheral neuropathy (pDPN) management among people with type 1/type 2 diabetes mellitus (T2DM).

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Key take away

Diabetic peripheral neuropathy is a devastating issue that involves nerve damage due to high blood glucose levels. Pregabalin is an FDA approved drug to counter DPN associated pain. The study helps to elucidate the efficacy of Pregabalin among type one and two diabetic patients.

Background

The study aimed to compare the Pregabalin safety and efficacy in concern to painful diabetic peripheral neuropathy (pDPN) management among people with type 1/type 2 diabetes mellitus (T2DM).

Method

Ten randomised clinical trials were analysed to collect the pooled data regarding change sleep disturbance and pain scores from baseline to 12 weeks and last observation carried forward (LOCF) using mixed model repeated measures (MMRM).  The Adverse events (AEs) were also noticed.

Result

Baseline demographic features were comparable in the placebo (T1DM/T2DM; 92/868) and pregabalin-treated (T1DM/T2DM; 1632/156) group. T1DM group patients were ∼10 years younger than T2DM patients. The mean ± SD baseline sleep and pain scores for Pregabalin and placebo noticed were (T1DM: 5.2 ± 2.4 and 5.2 ± 2.7; T2DM: 5.3 ± 2.5 and 5.1 ± 2.5) and (T1DM: 6.2 ± 1.4 and 6.5 ± 1.6; T2DM: 6.5 ± 1.5 and 6.4 ± 1.5). Mean CFB treatment differences (pregabalin minus placebo) measured by MMRM were considerably diverse for sleep and pain with each diabetes type (all weeks p < .05). With LOCF, Pregablin’s odds ratios (ORs) of achieving 30% pain reduction of Pregabalin’s were comparable with T1DM (2.01) and T2DM (1.91). ORs of 30% improvement in sleep quality of Pregabalin were 1.81 with T1DM and 2.01 with T2DM. The reported adverse events matched up with the known safety profile of Pregabalin.

Conclusion

Pregabalin improved pain and sleep quality remarkably, without a clinically meaningful variation between diabetes types.

Source:

Curr Med Res Opin

Article:

The efficacy of pregabalin for treating pain associated with diabetic peripheral neuropathy in subjects with type 1 or type 2 diabetes mellitus.

Authors:

B. Parsons et al.

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