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Effectiveness of Minodronic acid in prophylaxis of osteoporosis in premenopausal women

Minodronic acid Minodronic acid
Minodronic acid Minodronic acid

A single-centre, non-randomized controlled, experimental trial examined the effectiveness of Minodronic acid in preventing osteoporosis in premenopausal women who underwent bilateral oophorectomy for gynecologic illness.

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Key take away

In premenopausal women with gynecologic illness, Minodronic acid may prevent osteoporosis following oophorectomy independent of age at oophorectomy, adjuvant therapy, cancer type, or body mass index.

Background

A single-centre, non-randomized controlled, experimental trial examined the effectiveness of Minodronic acid in preventing osteoporosis in premenopausal women who underwent bilateral oophorectomy for gynecologic illness.

Method

For 101 individuals, data on bone alkaline phosphatase (BAP)/tartrate-resistant acid phosphatase 5 b (TRACP 5 b), young adult mean, and bone mineral density (BMD) from the femur and lumbar vertebrae were collected. The effectiveness of Minodronic acid in preventing osteoporosis was the major outcome ascertained. Overall, 55 and 31 subjects were allocated to medication and no medication groups, respectively.

Result

In the medication group, the rise in BAP/TRACP-5b and the decline in young adult mean and BMD were markedly more repressed. Adjuvant treatment, body mass index (BMI), cancer type, age at oophorectomy did not differ significantly between groups. The use of Minodronic acid did not cause any adverse events.

Conclusion

The use of Minodronic acid is associated with a reduction in the rise in BAP/TRACP 5b and the decline in BMD and young adult mean in premenopausal women with gynecologic disease following oophorectomy.

Source:

Journal of Obstetrics and Gynaecology

Article:

Efficacy of Minodronic acid for the prevention of osteoporosis in premenopausal women with gynaecologic disease who undergo bilateral oophorectomy: a single-centre, non-randomised controlled, experimental study

Authors:

Asumi Okumura et al.

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