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Effectiveness of Levetiracetam for migraine prophylaxis

Effectiveness of Levetiracetam for migraine prophylaxis Effectiveness of Levetiracetam for migraine prophylaxis
Effectiveness of Levetiracetam for migraine prophylaxis Effectiveness of Levetiracetam for migraine prophylaxis

This systematic review and meta-analysis examined the effectiveness of levetiracetam in migraine prophylaxis.

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Key take away

A moderate to severe persistent headache for 4-72 hours leads to a migraine. As the onset of migraine may be associated with cortical hyperexcitability, hence, antiepileptic drugs may be effective for the same. As examined from this study, the use of levetiracetam was beneficial in migraineurs given the unfavourable effects or teratogenicity of other preventive therapies.

Background

This systematic review and meta-analysis examined the effectiveness of levetiracetam in migraine prophylaxis.

Method

Some renowned databases- PubMed, EMBASE, and the Cochrane were explored for articles concerning relevant migraine prophylaxis and levetiracetam treatment. There were 3 main study outcomes: patients with >50% headache frequency decrease, headache frequency, and headache severity.

Result

All in all, four randomized controlled trial (RCTs) comprising of 192 patients and four prospective studies comprising of 85 patients were recognized. Significant differences were found between levetiracetam and the placebo groups and outcomes under consideration (Table 1):

Conclusion

Levetiracetam can considerably decrease headache frequency and severity. Thus, levetiracetam in oral formulation can be an effective treatment for migraine prophylaxis.

Source:

Journal of the Formosan Medical Association

Article:

Efficacy of levetiracetam for migraine prophylaxis: A systematic review and meta-analysis

Authors:

Po-Hua Yen et al.

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