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DHEA supplementation and miscarriage prevention: Optimizing serum estradiol in early pregnancy

Pregnancy DHEA Supplementation Pregnancy DHEA Supplementation
Pregnancy DHEA Supplementation Pregnancy DHEA Supplementation

In the context of early pregnancy, low levels of serum estradiol have been linked to an escalated risk of miscarriage. This retrospective cohort study aimed to decipher whether supplementing with estradiol or dehydroepiandrosterone (DHEA) could mitigate this risk within a comprehensive treatment approach targeting various symptoms.

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Key take away

In women experiencing low estradiol levels in early pregnancy, dehydroepiandrosterone supplementation boosts serum estradiol levels, indicating its potential to lower miscarriage risk in such pregnancies.

Background

In the context of early pregnancy, low levels of serum estradiol have been linked to an escalated risk of miscarriage. This retrospective cohort study aimed to decipher whether supplementing with estradiol or dehydroepiandrosterone (DHEA) could mitigate this risk within a comprehensive treatment approach targeting various symptoms.

Method

Women experiencing low serum estradiol levels during early pregnancy, defined as ≤50% of the reference levels based on gestational age were enrolled. Oral administration of either estradiol or DHEA was employed, with the primary focus on determining serum estradiol levels in relation to gestational age. Secondary endpoints encompassed  gestational age at delivery, birth weight, and miscarriage rates.

Result

Estradiol use did not considerably impact serum estradiol levels relative to gestational age, whereas DHEA use notably increased these levels. Among pregnancies characterized by low estradiol, the miscarriage rates in the non-supplemented, estradiol supplemented, and the DHEA supplemented groups are depicted in Table 1:

No noticeable differences were witnessed in preterm delivery rates, gestational age, size, or birth weight. Furthermore, no sexual abnormalities were documented in the offspring (n = 29) of patients who received DHEA supplementation during a follow-up period of 5-7 years.

Conclusion

DHEA supplementation effectively restored serum estradiol levels and contributed to a statistically significant curtailment in miscarriage rates when integrated into the treatment regimen.

Source:

Frontiers in Reproductive Health

Article:

Restoration of serum estradiol and reduced incidence of miscarriage in patients with low serum estradiol during pregnancy: a retrospective cohort study using a multifactorial protocol including DHEA

Authors:

Phil Boyle et al.

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