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The analgesic effect of non-steroidal anti-inflammatory drugs (NSAIDs) has been widely demonstrated, although the discussion on the ways these drugs achieve such an effect is far from being settled. Many data indicate that, beyond the primary action of prostaglandin synthesis inhibition in the periphery, NSAIDs are effective also at the central level, and that their anti-inflammatory and analgesic actions can be dissociated into peripheral and central components.
Possible central mechanisms determining the analgesic action of Ketorolac- a non-steroidal antiinflammatory drug (NSAID) have been investigated via an iontophoretic approach.
M.L. Sotgiu et al.rBrain Research 813 1998 223–226
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