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The autonomous cardiovascular control can contribute to progression of migraine.
This study
highlights the essentially modified autonomic regulation in almost all female
patients with episodic and chronic migraine. The cardinal outcome was that the
vascular control was consistent with view that migraine is associated with the
systemic vasculopathy.
The autonomous
cardiovascular control can contribute to progression of migraine. However,
current data on cardiovascular reactivity in migraine, especially severe forms,
are essentially contradictory. The main aim of this study was to compare the
autonomous regulation of circulation in patients with episodic and chronic
migraine and healthy subjects.
Seventy-three
migraine patients (mean age 35 ± 10) including episodic migraine (51 patients,
4–14 headache days/months) and chronic migraine (22 patients, ≥15 headache
days/month) along with age-match control (71 healthy voluntaries) were
examined. The autonomic regulation of circulation was examined with the
tilt-table test, a deep breathing and Valsalva Maneuver, handgrip test,
cold-stress vasoconstriction, arterial baroreflex and blood pressure
variability.
The changes in
heart rate induced by deep breathing, Valsalva Maneuver, and blood pressure in
tilt-table test in patients with migraine did not differ from the control
group. In contrast, the values of cold-stress-vasoconstriction forearm
blood-flow reactivity (p <0.001), the increase in diastolic blood pressure
in handgrip test (p <0.001), mean blood pressure in the late stage of the
second phase of Valsalva Maneuver (p <0.001) and blood pressure variability
(p <0.005) were all higher in patients with migraine than in the control
group.
Thus, both
episodic and chronic migraine are associated with significant disturbances in
autonomous control resulting in enhanced vascular reactivity whereas the
cardiac regulation remains largely unchanged.
J Headache Pain 2016 Dec;17(1):52
Autonomous control of cardiovascular reactivity in patients with episodic and chronic forms of migraine
Oleg V. Mamontov et al.
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