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Association between white matter lesions and H. pylori infection in migraine patients

H. pylori and migraine H. pylori and migraine
H. pylori and migraine H. pylori and migraine

A retrospective analysis was carried out to explore the relation between white matter lesions (WML) and Helicobacter pylori (H. pylori) infection in episodic migraine patients.

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Key take away

In people diagnosed with migraine, H. pylori infection can be deemed as a risk factor in the development of white matter lesions.

Background

A retrospective analysis was carried out to explore the relation between white matter lesions (WML) and Helicobacter pylori (H. pylori) infection in episodic migraine patients.

Method

Overall, 526 people (mean age 45.57 ± 13.46 years) suffering from episodic migraine were enrolled. With brain magnetic resonance imaging (MRI) examinations, the hyperintensity of WML had been formerly assessed in these patients.

Recording of former endoscopic gastric biopsy histopathological assessment and reports on H. pylori findings was done. The demographic properties of patients, like gender, age, and chronic systemic diseases like diabetes mellitus (DM) and hypertension were recorded. Statistical assessment was made.

Result

In 33.8% (n = 178) of H. pylori-infected patients, WML was seen at a 2.5-fold greater occurrence on their brain MRI (odds ratio: 2.562). Contrasted to people without migraine and hypertension, WML was more profound in people with migraine and hypertension. Older age was also related to WML (odds ratio = 1.07). As per the multivariate logistic regression analysis, hypertension + DM, hypertension, H. pylori, and age had remarkable correlations in predicting WML. Compared to other variables,  hypertension exhibited a greater odds ratio value.

Conclusion

The presence of H. pylori was associated with a rise in WML development in migraine patients. Hence, H. pylori elimination may aid to lower WML risk in migraine.

Source:

BMC Neurology

Article:

Relationship between Helicobacter pylori infection and white matter lesions in patients with migraine

Authors:

Serkan Öcal et al.

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