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To estimate the diagnostic performance of a total of 5 RAD assays for diagnosis of COVID-19. And, to illustrate the execution and effect of the implementation of recently CE-approved point-of-care diagnostic test at the casualty department.
As
concluded from this study, all rapid nucleocapsid protein antigen detection (RAD) assays were found to
be less sensitive as compared to the existing diagnostic test, rRT-PCR. Given the
high incidence of COVID-19, the RAD tests can be effectively used as a rapid
screening tool, to monitor preventive measures associated with the infection
and assist in targeted admission to respective wards.
To estimate the diagnostic performance of a total of 5
RAD assays for diagnosis of COVID-19. And, to illustrate the execution and
effect of the implementation of recently CE-approved point-of-care
diagnostic test at
the casualty department.
The precision of the 5 RAD assays under study were
examined on 100 respiratory samples. In these samples, 60 were real-time
reverse-transcriptase-polymerase chain reaction (rRT-PCR) confirmed COVID-19
positive samples, 24 were COVID-19 RNA negative samples and 16 were samples
positive for other respiratory infectious agents. The study researchers
modified the company’s procedure, to confirm the antigen tests on transport
media used for rRT-PCR in daily practice.
The CE-approved point-of-care diagnostic test, one of the tests
under consideration, was
executed as screening tool for quick diagnosis and targeted admission.
Sensitivity of the included RAD assays varied from 88.9% to 100% for samples with Ct less than 26, and the specificity varied from 46.2% to 100%. During the execution phase, a total of 4195 RAD tests were accomplished. Based on the result of the rapid RAD, 157 patients were relocated directly to the COVID-19 cohort and not the general ward (47 patients) or the provisional COVID-19 ward (110 patients).
Three
antigen tests were found to have a satisfactory overall performance and seem to
be able to distinguish most of the patients with COVID-19.
Journal of Hospital Infection
Comparison of five SARS-CoV-2 rapid antigen tests in a hospital setting and performance of one antigen assay in routine practice. A useful tool to guide isolation precautions?
EvelineVan Honacker et al.
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