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Aspirin found to be beneficial in criticall ill COVID-19 patients

Aspirin found to be beneficial in criticall ill COVID-19 patients Aspirin found to be beneficial in criticall ill COVID-19 patients
Aspirin found to be beneficial in criticall ill COVID-19 patients Aspirin found to be beneficial in criticall ill COVID-19 patients

To examine if the use of aspirin is linked with lessened risk of mechanical ventilation, ICU admission, and mortality in the hospital.

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Key take away

COVID-19 is linked with hypercoagulability and higher thrombotic risk in terminally ill patients. In this observational cohort study of 412 COVID-19 patients, the use of aspirin or acetylsalicylic acid was linked with a significantly decreased mechanical ventilation, intensive care unit (ICU) admission, and mortality risk following the adjustment for confounding variables.

Background

To examine if the use of aspirin is linked with lessened risk of mechanical ventilation, ICU admission, and mortality in the hospital.

Method

Four hundred twelve adult patients admitted with COVID-19 to multiple hospitals were considered for this study. The requirement for mechanical ventilation was the primary outcome. ICU admission and mortality in the hospital were the secondary outcomes. 

Result

Apart from 314 patients (76.3%), 98 patients (23.7%) got aspirin within 1 day of the hospital admission or 7 days prior to the admission. Aspirin use had a crude association with reduced mechanical ventilation and ICU admission, but no crude association with mortality as shown in the below table:


Aspirin use was independently linked with lower risk of mechanical ventilation, ICU admission, and in-hospital mortality after adjustment for 8 confounding variables. No variations in major bleeding or overt thrombosis amongst users and non- users of aspirin were found.

Conclusion

Aspirin or acetylsalicylic acid may be linked with better outcomes in patients who are hospitalized due to Coronavirus. Future studies are required to evaluate whether a connecting relationship is present between aspirin use and decreased lung injury and mortality in patients suffering from COVID-19.

Source:

Anesthesia & Analgesia

Article:

Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019

Authors:

Jonathan H. Chow et al.

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