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Acotiamide + Esomeprazole for management of functional dyspepsia symptoms

Functional dyspepsia Functional dyspepsia
Functional dyspepsia Functional dyspepsia

A prospective observational study was conducted to evaluate the impact of Acotiamide + Esomeprazole therapy on improving symptoms associated with functional dyspepsia, as compared to using Acotiamide or Esomeprazole alone.

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Key take away

Compared to monotherapy, the combination of Acotiamide and Esomeprazole is effective to mitigate symptoms in patients suffering from functional dyspepsia.

Background

A prospective observational study was conducted to evaluate the impact of Acotiamide + Esomeprazole therapy on improving symptoms associated with functional dyspepsia, as compared to using Acotiamide or Esomeprazole alone.

Method

The study recruited patients who were diagnosed with functional dyspepsia as per the Rome IV criteria. Group 1 received Acotiamide, Group 2 received Esomeprazole, and Group 3 received a combination therapy of Acotiamide and Esomeprazole for 6 weeks. With the aid of a symptom assessment scale,  effectiveness was examined. Additional measurements including responder rate, resolution rate, and treatment-emergent adverse events were also determined.

Result

Overall, 52 subjects successfully concluded the study in each of the three groups. Notably, all three intervention groups demonstrated clinically meaningful improvements in the symptom assessment scale for Total Abdominal Symptom, Postprandial distress syndrome, and Epigastric pain syndrome scores from the beginning of the study to 6-weeks. The combination therapy group (Group 3) exhibited the most significant decline in scores from baseline to week 6, as depicted in Table 1:

Nasopharyngitis, diarrhea, headache, and fever were some commonly reported adverse events.

Conclusion

The combination therapy involving Acotiamide and Esomeprazole was beneficial in decreasing symptom scores after 6-weeks in patients with functional dyspepsia, in comparison to using either of the drugs alone.

Source:

Research Journal of Pharmacy and Technology

Article:

Effect of Acotiamide and Esomeprazole combination therapy on Functional Dyspepsia symptoms in comparison with Acotiamide or Esomeprazole Monotherapy: A Prospective Observational Study

Authors:

Dhruva Bhat et al.

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