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To study an analgesic role of melatonin in the treatment of low back pain.
Melatonin is a
manmade form of a hormone produced in the brain that helps regulate your sleep
and wake cycle. In this original research, melatonin is regarded as a drug of
choice in the treatment of low back pain due to its therapeutic efficacy and
good tolerability.
To study an
analgesic role of melatonin in the treatment of low back pain.
A study included
178 patients, aged from 40 to 65 years, with low back pain during at least 12
weeks and the VAS score > 3. Patients were stratified into 6 groups (3 pairs
of comparison). In the first pair, patients of the main group (n = 31) received
APTPA (a combination of 500 mg of glucosamine hydrochloride and 500 mg of chondroitin
sulfate) in dosage 1 tablet twice a day during 1 month and then 1 tablet during
2 months plus melaxen (3 mg of melatonin 30-40 min before sleep), patients of
the control group (n = 29) received only APTPA. In the second pair, patients of
the comparison group (n = 30) received APTPA in dosage 1 tablet twice a day and
diclofenac in dosage 25 mg 2-3 times a day, patients of the main group (n = 30)
received additionally melaxen (3 mg of melatonin 30-40 min before sleep). In
the third pair, patients of the main group (n = 29) received APTPA in dosage 1
tablet twice a day, diclofenac in dosage 25 mg 2-3 times a day and melaxen (3
mg of melatonin 30-40 min before sleep), patients of the comparison group (n =
29) did not receive melaxen. Treatment results were assessed after 3 months for
the first pair and after 1 month for the second and third pairs.
A significant
reduction in pain intensity at movement and resting state was noted in the main
groups compared to controls.
Possible mechanisms
of analgesic properties of melatonin and world experience in chronic low back
pain treatment are discussed.
Zh Nevrol Psikhiatr Im S S Korsakova. 2015
A role of melatonin in the treatment of low back pain
Kurganova YM, Danilov AB
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