EN | RU
EN | RU

Help Support

Back

Topiramate versus flunarizine to resolve non-headache symptoms of migraine

Topiramate versus flunarizine to resolve non-headache symptoms of migraine Topiramate versus flunarizine to resolve non-headache symptoms of migraine
Topiramate versus flunarizine to resolve non-headache symptoms of migraine Topiramate versus flunarizine to resolve non-headache symptoms of migraine

What's new?

Flunarizine and topiramate found to resolve the non-headache symptoms of migraine efficiently.

The classical drugs for migraine prophylaxis; flunarizine and topiramate are significantly effective in managing the non-headache symptoms of migraine says a recently published study in The International Journal of Neuroscience. This study was conducted to investigate the comparative effectiveness of flunarizine versus topiramate on the non-headache symptoms of migraine and alterations in prolactin and dopamine levels before and after the treatment.


The study population involved 66 individuals having an episodic migraine. Participants were randomly fractionated into either the flunarizine arm or topiramate arm.

It was observed that the non-headache symptoms of migraine in both the arms were notably better post-therapy compared to pre-therapy in the premonitory, headache and resolution phases.


In flunarizine arm, the prolactin levels (t=-4.097) were higher and dopamine levels (t = 1.909) were lower compared to before treatment. However, no significant difference was observed in the dopamine (t = 1.556) and prolactin (t = 1.099) levels before and after topiramate therapy.


The above observations portray the comparable efficacy of flunarizine and topiramate and the involvement of dopamine-prolactin axis as an underlying mechanism of the flunarizine for the treatment of non-headache symptoms of migraine.

Source:

The International Journal of Neuroscience

Article:

The effect of topiramate versus flunarizine on the non-headache symptoms of migraine

Authors:

Wei Li et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ua
Try: