EN | RU
EN | RU

Help Support

Back

Study investigates association between 18F-THK5351 positivity and cognitive decline

cognitive_impairment cognitive_impairment
cognitive_impairment cognitive_impairment

What's new?

β-amyloid negative amnestic mild cognitive impairment people with 18F-THK5351 positivity exhibited a worse cognitive trajectory compared to people with 18F-THK5351 negativity.

According to the findings of a study, increased 18F-THK5351 uptake may be a valuable predictor of poor prognosis among β-amyloid negative amnestic mild cognitive impairment people, which may be linked with increased neuroinflammation in the brain. Researchers assessed the association between 18F-THK5351 positron emission tomography positivity and cognitive dysfunction in people with mild cognitive decline.

Overall, 25 participants who underwent at least 2 follow-up neuropsychological assessments, including clinical dementia rating-sum of boxes (CDR-SOB) were segregated into 18F-THK5351-positive (n=10) and 18F-THK5351-negative (n=15) arms. For estimating the effects of 18F-THK5351 positron emission tomography positivity on cognitive prognosis among β-amyloid negative-cognitive impairment people, a linear mixed-effects model was utilized. Among 25 β-amyloid negative- amnestic mild cognitive impairment people, 10 (40.0%) were found to be 18F-THK5351 positive.

Subjects in the 18F-THK5351-positive group were older when compared to the 18F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years). Regarding the percentage of apolipoprotein E ε4 carriers,  no profound inter-group difference was witnessed. In comparison with the 18F-THK5351-negative group, the 18F-THK5351-positive group exhibited a faster deterioration of CDR-SOB scores.

Source:

The Yonsei Medical Journal

Article:

18 F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment

Authors:

Min Young Chun et al.

Comments (0)

You want to delete this comment? Please mention comment Invalid Text Content Text Content cannot me more than 1000 Something Went Wrong Cancel Confirm Confirm Delete Hide Replies View Replies View Replies en ru
Try: