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Study found elobixibat to be an effective bowel preparation agent for colonoscopy

Study found elobixibat to be an effective bowel preparation agent for colonoscopy Study found elobixibat to be an effective bowel preparation agent for colonoscopy
Study found elobixibat to be an effective bowel preparation agent for colonoscopy Study found elobixibat to be an effective bowel preparation agent for colonoscopy

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Elobixibat plus 1 L polyethylene glycol along with ascorbic acid can be used for cleansing the colon prior to colonoscopy.

Given the bowel cleansing effect and reduced sleep disturbance, a combination of elobixibat (ileal bile acid transporter inhibitor) and 1 L of polyethylene glycol along with ascorbic acid (PEG-Asc) can be regarded as a bowel cleansing formulation for colonoscopy, as per the outcomes of a randomized study published in Digestive Endoscopy.

Daisuke Yamaguchi and researchers investigated the efficacy, safety, and tolerability of elobixibat plus PEG-Asc solution as compared to sodium picosulfate plus PEG-Asc solution as bowel preparation agent in adult patients scheduled for an elective colonoscopy.

In this multi-center, observer-blinded, non-inferiority, prospective study, out of 210 patients, 196 patients were assigned to (i) Group A (99 patients): Received elobixibat plus 1-L PEG-Asc, (ii)  Group B (97 patients): Received sodium picosulfate plus 1-L PEG-Asc. Boston Bowel Preparation Scale (BBPS) was utilized to evaluate bowel cleansing quality in both arms. Bowel preparation time, tolerability, and adverse events were noted.

Group A and B had comparable BBPS and bowel preparation time. The adequate bowel preparation rate was less in group A vs. group B. The sleep disturbance was considerably less frequent in group A compared to group B, as depicted in the below table 1:


Thus, a combination of elobixibat and PEG-Asc can be used as an alternative bowel preparation agent for elective colonoscopy. 

Source:

Digestive Endoscopy

Article:

The efficacy of elobixibat as bowel preparation agent for colonoscopy: A prospective, randomized, multi-center study

Authors:

Daisuke Yamaguchi et al.

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