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RT-LAMP test is an easy, rapid, extraction-free salivary test for SARS-CoV-2 detection.
A monocentric diagnostic study published in Scientific Reports depicted that for SARS-CoV-2 detection, a rapid and connected reverse-transcription loop-mediated isothermal amplification (RT-LAMP) test on self-collected saliva is reliable. Researchers aimed to explore the diagnostic performances of RT-LAMP assay on symptomatic and asymptomatic people in an ambulatory screening.
Collection of saliva and nasopharyngeal swabs was done from 443 outpatients and tested by a reference standard test, that is, reverse-transcription quantitative polymerase chain reaction (RT-qPCR). A total of 71 people (16.0%) were positive by salivary and/or nasopharyngeal RT-qPCR. The sensitivity and specificity of salivary RT-LAMP are shown in Table 1:
For both asymptomatic and symptomatic people, the performances were similar. Furthermore, SARS-CoV-2 genetic variants were assessed and no dominant mutation in the RT-LAMP primer region was noted during the study period. Thus, the salivary RT-LAMP assay is an operational substitute for coronavirus detection in view of safe economic and social reopening.
Scientific Reports
Performances of rapid and connected salivary RT-LAMP diagnostic test for SARS-CoV-2 infection in ambulatory screening
Francisco Santos Schneider et al.
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